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Exposure to opioids such as oxycodone results in a greater than six-fold increase in expression in rat liver of glutathione S-transferase A-5, an enzyme that catalyzes conjugation of glutathione to toxic substances, while the expression of the cytochrome enzyme CYP3A2 is decreased seven-fold [24]

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The post adds that GLP-1 therapy may raise serum uric acid through weight-loss-related shifts in purine metabolism